Three-Dimensional Docking in the MAPK p38α

  title={Three-Dimensional Docking in the MAPK p38$\alpha$},
  author={Elizabeth J. Goldsmith},
  journal={Science Signaling},
  pages={pe47 - pe47}
  • E. Goldsmith
  • Published 2011
  • Biology, Medicine
  • Science Signaling
Structural analysis reveals the mode of interaction between a mitogen-activated protein kinase and its inactivating phosphatase. Mitogen-activated protein kinases (MAPKs) are central players in eukaryotic signaling circuitry and interact with numerous other proteins. The structure of a MAPK with a kinase-binding domain (KBD) from a MAPK phosphatase, MKP5, reveals that the contacts with the MAPK are made with the folded three-dimensional KBD, although the KBD occupies the same binding site on… Expand

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