Three-Dimensional Cell and Tissue Patterning in a Strained Fibrin Gel System

  title={Three-Dimensional Cell and Tissue Patterning in a Strained Fibrin Gel System},
  author={Takuya Matsumoto and J. Sasaki and Eben Alsberg and Hiroshi Egusa and Hirofumi Yatani and Taiji Sohmura},
  journal={PLoS ONE},
  pages={1425 - 1428}
Techniques developed for the in vitro reproduction of three-dimensional (3D) biomimetic tissue will be valuable for investigating changes in cell function in tissues and for fabricating cell/matrix composites for applications in tissue engineering techniques. In this study, we show that the simple application of a continuous strain to a fibrin gel facilitates the development of fibril alignment and bundle-like structures in the fibrin gel in the direction of the applied strain. Myoblasts… CONTINUE READING


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