Three‐Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

@article{Sivakolundu2019ThreeDimensionalLP,
  title={Three‐Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis},
  author={Dinesh K. Sivakolundu and Madison Hansen and Kathryn L. West and Yeqi Wang and Thomas Stanley and Andrew Wilson and Morgan McCreary and Monroe P. Turner and Marco C. Pinho and Braeden D. Newton and Xiaohu Guo and Bart Rypma and Darin T. Okuda},
  journal={Journal of Neuroimaging},
  year={2019},
  volume={29}
}
Multiple sclerosis (MS) clinical management is based upon lesion characterization from 2‐dimensional (2D) magnetic resonance imaging (MRI) views. Such views fail to convey the lesion‐phenotype (ie, shape and surface texture) complexity, underlying metabolic alterations, and remyelination potential. We utilized a 3‐dimensional (3D) lesion phenotyping approach coupled with imaging to study physiologic profiles within and around MS lesions and their impacts on lesion phenotypes. 
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