Three's company: two or more unrelated receptors pair with the same ligand.

@article{BenShlomo2005ThreesCT,
  title={Three's company: two or more unrelated receptors pair with the same ligand.},
  author={Izhar Ben-Shlomo and Aaron J Hsueh},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 5},
  pages={1097-109}
}
Intercellular communication relies on signal transduction mediated by extracellular ligands and their receptors. Although the ligand-receptor interaction is usually a two-player event, there are selective examples of one polypeptide ligand interacting with more than one phylogenetically unrelated receptor. Likewise, a few receptors interact with more than one polypeptide ligand, and sometimes with more than one coreceptor, likely through an interlocking of unique protein domains. Phylogenetic… CONTINUE READING

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