Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming.

@article{Choi2014Thrap3DO,
  title={Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming.},
  author={Jang Hyun Choi and Sun-Sil Choi and Eun Sun Kim and Mark P. Jedrychowski and Yong Yang and Hyun-Jun Jang and Pann-Ghill Suh and Alexander S Banks and Steven P Gygi and Bruce M. Spiegelman},
  journal={Genes & development},
  year={2014},
  volume={28 21},
  pages={2361-9}
}
Phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) at Ser273 by cyclin-dependent kinase 5 (CDK5) in adipose tissue stimulates insulin resistance, but the underlying molecular mechanisms are unclear. We show here that Thrap3 (thyroid hormone receptor-associated protein 3) can directly interact with PPARγ when it is phosphorylated at… CONTINUE READING