Thr270Ile in embC (Rv3793) is not a marker for ethambutol resistance in the Mycobacterium tuberculosis complex.

Abstract

We thank Goude et al. for their extensive study of the role of embC (Rv3793) in ethambutol (EMB) resistance in Mycobacterium tuberculosis (9). Their finding that the Thr270Ile change on its own plays no role in EMB resistance is of particular importance (9). Clinical studies had found this mutation in numerous EMB-resistant but also some EMB-sensitive… (More)
DOI: 10.1128/AAC.01607-10

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