Thousands of chemical starting points for antimalarial lead identification

@article{Gamo2010ThousandsOC,
  title={Thousands of chemical starting points for antimalarial lead identification},
  author={Francisco Javier Gamo and Laura M Sanz and Jaume Vidal and Cristina de Cozar and Emilio Alvarez and Jos{\'e} Lu{\'i}s Lavandera and Dana E. Vanderwall and Darren V. S. Green and Vinod Kumar and Samiul Hasan and James R. Brown and Catherine E. Peishoff and Lon R. Cardon and Jose F. Garc{\'i}a-Bustos},
  journal={Nature},
  year={2010},
  volume={465},
  pages={305-310}
}
Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline’s chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 µM… 
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