Thorotrast-induced cholangiocarcinoma: case report

Thorotrast-induced cholangiocarcinoma: case report},
  author={D V Sahani and S. R. Prasad and K. K. Tannabe and Peter F. Hahn and Peter R. Mueller and Sanjay Saini},
  journal={Abdominal Imaging},
AbstractThorotrast, a contrast medium used extensively before being banned in 1950s, delivers a densely ionizing, high linear energy transfer type of radiation that predisposes to malignancies. We report a case of peripheral cholangiocarcinoma and describe its computed tomographic and magnetic resonance imaging features in a patient who developed it 48 years after exposure to Thorotrast.  

Radiation-induced cholangitis with hepatocellular carcinoma.

Diagnosis and Management of Intrahepatic and Extrahepatic Cholangiocarcinoma.

In this chapter, the risk factors, clinical presentation, and management of cholangiocarcinoma are reviewed.

Anaphylactoid and adverse reactions to radiocontrast agents.

  • J. Hagan
  • Medicine
    Immunology and allergy clinics of North America
  • 2004

Distal biliary malignancy.

Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma is a relatively rare disease with a poor prognosis; nevertheless, unresectable patients could be treated in a multimodality strategy with a significant improvement in terms of survival.

Point-of-Care Clinical Guide: Cholangiocarcinoma

Factors most commonly associated with disease development, available treatments, and anticipated outcomes for cholangiocarcinoma are discussed.

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Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009.

Magnetic resonance imaging/magnetic resonance cholangiopancreatography, positron emission tomography scan, endoscopic ultrasound and computed tomography scans are the most frequently used modalities for diagnosis and tumor staging.

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

A case of hypercalcemia presenting as the first manifestation of an underlying rare variant of intrahepatic cholangiocarcinoma is reported, which led to an urgent inpatient treatment with gemcitabine/cisplatin combination chemotherapy to control the aggressive nature of the malignancy.



MRI in thorotrastosis.

The german thorotrast study: recent results and assessment of risks.

The German Thorotrast study comprises 2,326 patients and 1,890 controls and the cumulative risk estimate for liver cancer and hematopoietic malignancies is lower by a factor of 10 compared to the results of the Life Span Study.

Intrahepatic cholangiocarcinoma: MRI and pathologic correlation in 14 patients.

The study suggests that the MR features of intrahepatic cholangiocarcinoma are well correlated with pathologic findings, but are nonspecific.

Pathomorphologic characteristics of 102 cases of thorotrast‐related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma

Findings suggest that Th influences are more carcinogenic to epithelial cells of the bile duct and sinusoidal lining cells than hepatocytes.

Intrahepatic peripheral cholangiocarcinoma: comparison of dynamic CT and dynamic MRI.

D-CT is better than D- MRI for demonstrating vascular involvement and extrahepatic invasion, and D-MRI gives more conspicuous enhancement, which can provide important information for the diagnosis of PCC.

High rate of small TP53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with thorotrast: implications for alpha-particle carcinogenesis.

The low frequency of changes in the TP53 gene in the liver tumors related to Thorotrast suggests that the genetic changes were not caused mainly by direct actions of alpha particles but rather by indirect effects that may have been due to cycles of necrosis and regeneration.

MRI appearance of thorotrast-induced cholangiocarcinoma in a case of thorotrastosis.

The case of a 71-year-old man with thorotrastosis and a cholangiocarcinoma detected by MRI is presented, and the radiographic appearance of the cholangiocarcinoma is discussed. We concluded that MR

Intrahepatic peripheral cholangiocarcinoma: CT evaluation

In the proper clinical setting, detection of a hypodense hepatic lesion with peripheral enhancement, biliary dilatation, and contrast enhancement on delayed images are highly suggestive of peripheral intrahepatic cholangiocarcinoma.