Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species.

@article{Charan2001ThorectandrolsAA,
  title={Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species.},
  author={Romila D. Charan and Tawnya Carlene McKee and Michael R. Boyd},
  journal={Journal of natural products},
  year={2001},
  volume={64 5},
  pages={661-3}
}
Two new sesterterpenes, thorectandrol A (1) and B (2), were isolated from extracts of the marine sponge Thorectandra sp. The structures were determined by extensive NMR spectral data analysis. NOE correlations were used to define the relative stereochemistry of 1 and 2, while CD data were used to suggest their absolute stereochemistry. Both compounds 1 and 2 inhibited the growth of MALME-3M (melanoma) and MCF-7 (breast) cancer cell lines in the range 30-40 microg/mL. The known compound… CONTINUE READING

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