Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel

@article{Umanah2017ThoraseVA,
  title={Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel},
  author={George K E Umanah and Marco Pignatelli and Xiling Yin and Rong Chen and Joshua A Crawford and Stewart Neifert and Leslie Scarffe and Adam A Behensky and Noah Guiberson and Melissa X.-L. Chang and Erica Ma and Jin Wan Kim and Cibele C Castro and Xiaobo Mao and Li Chen and Shaida A Andrabi and Mikhail V. Pletnikov and Ann E Pulver and Dimitrios Avramopoulos and Antonello Bonci Bonci and David Valle and Ted M Dawson and Valina L Dawson},
  journal={Science Translational Medicine},
  year={2017},
  volume={9}
}
The AAA+ adenosine triphosphatase (ATPase) Thorase plays a critical role in controlling synaptic plasticity by regulating the expression of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Bidirectional sequencing of exons of ATAD1, the gene encoding Thorase, in a cohort of patients with schizophrenia and healthy controls… CONTINUE READING