Thiyl radicals in biological systems: significant or trivial?

  title={Thiyl radicals in biological systems: significant or trivial?},
  author={Balaraman Kalyanaraman},
  journal={Biochemical Society symposium},
Thiyl radicals are formed from one-electron oxidation of thiols. Thiyl radicals participate in a number of reactions including electron transfer, hydrogen abstraction and addition reactions with several biological constituents and xenobiotics. Thiyl radicals can be detected by optical spectroscopy or by electron spin resonance (ESR) spectroscopy. Thiyl radicals appear to play a role in the nitrosylation of thiols and protein thiols. The exact mechanism of thiol-induced enhancement of oxidative… CONTINUE READING