This information is current as of Nox 2 Activity in Macrophages Cutting Edge : Slamf 8 Is a Negative Regulator

@inproceedings{Wang2012ThisII,
  title={This information is current as of Nox 2 Activity in Macrophages Cutting Edge : Slamf 8 Is a Negative Regulator},
  author={Guoxing Wang and Ana C. Abadı́a-Molina and Scott B. Berger and Xavier Romero and Michael S. O’Keeffe and Domingo I. Rojas-Barros and Marta Aleman and Gongxian Liao and Elena Maganto-Garcı́a and Manuel Rivas del Fresno and Ninghai Wang and Cynthia Detre and Cox Terhorst},
  year={2012}
}
Slamf8 (CD353) is a cell surface receptor that is expressed upon activation of macrophages (MFs) by IFN-g or bacteria. In this article, we report that a very high NADPH oxidase (Nox2) enzyme activity was found in Slamf8 2/2 MFs in response to Escherichia coli or Staphylococcus aureus, as well as to PMA. The elevated Nox2 activity in Slamf8 2/2 MFs was also demonstrated in E. coli or S. aureus phagosomes by using a pH indicator system and was further confirmed by a reduction in the enzyme… CONTINUE READING