This information is current as Mechanisms Hemoglobin via Autocrine and Paracrine CD 163 and IgG Codefend against Cytotoxic Ho and

Lysis of RBCs during numerous clinical settings such as severe hemolytic anemia, infection, tissue injury, or blood transfusion releases the endogenous damage-associated molecular pattern, hemoglobin (Hb), into the plasma. The redox-reactive Hb generates cytotoxic reactive oxygen species, disrupting the redox balance and impairing the immune-responsive… CONTINUE READING