This information is current as Lupus Erythematosus Immunostimulatory Molecules in Systemic Damage , Infiltrate Tissues , and Expose Netting Neutrophils Induce Endothelial

@inproceedings{Villanueva2011ThisII,
  title={This information is current as Lupus Erythematosus Immunostimulatory Molecules in Systemic Damage , Infiltrate Tissues , and Expose Netting Neutrophils Induce Endothelial},
  author={Eneida C. Villanueva and Srilakshmi Yalavarthi and Celine C. Berthier and Jeffrey B. Hodgin and Ritika Khandpur and Andrew Tien-Shun Lin and Cory J. Rubin and Wenpu Zhao and Stephen H. Olsen and Matthew W. Klinker and David Shealy and Michael F Denny and Joel Plumas and Laurence Chaperot and Matthias Kretzler},
  year={2011}
}
An abnormal neutrophil subset has been identified in the PBMC fractions from lupus patients. We have proposed that these low-density granulocytes (LDGs) play an important role in lupus pathogenesis by damaging endothelial cells and synthesizing increased levels of proinflammatory cytokines and type I IFNs. To directly establish LDGs as a distinct neutrophil subset, their gene array profiles were compared with those of autologous normal-density neutrophils and control neutrophils. LDGs… CONTINUE READING
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