This information is current as Immunotherapy and Increases the Therapeutic Potential of TumorsEnhances Lymphocyte Infiltration in to Neoangiogenic Vessels α Targeting TNF -

Abstract

Abnormal tumor vasculature impairs T lymphocyte adhesion to endothelial cells and lymphocyte extravasation into neoplastic tissues, limiting the therapeutic potential of both active and adoptive immunotherapies. We have found that treatment of tumor-bearing mice with NGR-TNF, a Cys-Asn-Gly-Arg-Cys peptide-TNF fusion product capable of altering the… (More)

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