This information is current as-Chain Diversity β Governed by TCR Antigen Specificity of Type I NKT Cells Is


NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly invariant TCR a-chain usage (Va14-Ja18 in mice, Va24-Ja18 in humans). However, these cells have diverse TCR b-chains, including Vb8, Vb7, and Vb2 in mice and Vb11 in humans, joined to a range of TCR Db and Jb genes. In this study… (More)

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