Thirty years of synaptosome research.

  title={Thirty years of synaptosome research.},
  author={Victor P. Whittaker},
  journal={Journal of neurocytology},
  volume={22 9},
Detached synapses (synaptosomes), first isolated by the author in 1958 and identified as such in 1960, are sealed presynaptic nerve terminals often with a portion of the target cell--sometimes amounting to a complete dendritic spine--adhering to their external surface. They can be prepared in high yield from brain tissue and also in decreasing yield from spinal cord, retina, sympathetic ganglia, myenteric plexus and electric organs. They are sealed structures which, under metabolizing… CONTINUE READING

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