Thirty years of research on atrial natriuretic factor: historical background and emerging concepts.

@article{Bold2011ThirtyYO,
  title={Thirty years of research on atrial natriuretic factor: historical background and emerging concepts.},
  author={Adolfo J. de Bold},
  journal={Canadian journal of physiology and pharmacology},
  year={2011},
  volume={89 8},
  pages={527-31}
}
The discovery of the natriuretic properties of atrial muscle extracts pointed to the existence of an endocrine function of the heart that is now known to be mediated by the polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP). On the basis of such a finding, approximately 27 000 publications to date have described a wide variety of biological properties of the heart hormones as well as their application as therapeutic agents and biomarkers of cardiac disease… CONTINUE READING

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