Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

@article{Bertram2008ThirtyYO,
  title={Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses},
  author={Lars Bertram and Rudolph E. Tanzi},
  journal={Nature Reviews Neuroscience},
  year={2008},
  volume={9},
  pages={768-778}
}
The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early successes in identifying three genes that cause early-onset familial AD (those that encode amyloid precursor protein (APP) and the presenilins (PSEN1 and PSEN2)), and one genetic risk factor for late-onset AD (the gene that encodes apolipoprotein E (APOE)). A large number of studies that aimed to help uncover the remaining disease-related loci have been published in recent decades, collectively proposing… Expand
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