Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?

@article{Mailman2010ThirdGA,
  title={Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?},
  author={Richard B. Mailman and Vishakantha Murthy},
  journal={Current pharmaceutical design},
  year={2010},
  volume={16 5},
  pages={
          488-501
        }
}
Functional selectivity is the term that describes drugs that cause markedly different signaling through a single receptor (e.g., full agonist at one pathway and antagonist at a second). It has been widely recognized recently that this phenomenon impacts the understanding of mechanism of action of some drugs, and has relevance to drug discovery. One of the clinical areas where this mechanism has particular importance is in the treatment of schizophrenia. Antipsychotic drugs have been grouped… CONTINUE READING
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