Third-generation antidepressants: do they offer advantages over the SSRIs?

  title={Third-generation antidepressants: do they offer advantages over the SSRIs?},
  author={James S Olver and Graham Dene Burrows and Trevor R. Norman},
  journal={CNS drugs},
  volume={15 12},
Third-generation antidepressants are a group of antidepressant agents of variable action, not confined to serotonin reuptake inhibition. These agents include venlafaxine, reboxetine, nefazodone and mirtazapine. Claims have been made for these agents in terms of improved efficacy, faster speed of onset of effect and greater safety in the treatment of depression compared with previous medications, such as the selective serotonin reuptake inhibitors (SSRIs). This article reviews the evidence for… CONTINUE READING
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