Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases.

@article{StckelMaschek2000ThioxoAA,
  title={Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases.},
  author={Angela St{\"o}ckel-Maschek and Carmen Mrestani-Klaus and Beate Stiebitz and Hans-Ulrich Demuth and Klaus Neubert},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1479 1-2},
  pages={15-31}
}
Aminopeptidase P (APP), dipeptidyl peptidase II (DP II), dipeptidyl peptidase IV (DP IV) and prolyl oligopeptidase (POP) are proline specific peptidases. Hence, they are able to cleave peptide bonds containing the imino acid proline. Amino acid pyrrolidides (Pyrr) and thiazolidides (Thia) are well-known product analogue inhibitors of DP IV and POP. For the first time we describe the influence of a thioxo amide bond, incorporated into these compounds, on the inhibition of the proline specific… CONTINUE READING
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