Thiourea/proline derivative-catalyzed synthesis of tetrahydrofuran derivatives: a mechanistic view.


A thiourea/proline derivative-catalyzed synthesis of linear α-substituted tetrahydrofuran/pyran derivatives starting with lactol substrates is presented. This study demonstrates the utility and potential complications of using (thio)urea/proline cocatalysis as each of these catalysts is necessary to provide the observed reactivity, but a time-dependent… (More)
DOI: 10.1021/jo200838v


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