• Corpus ID: 222404339

Thiothixene versus trifluoperazine in newly-admitted schizophrenic patients.

@article{Mp1966ThiothixeneVT,
  title={Thiothixene versus trifluoperazine in newly-admitted schizophrenic patients.},
  author={Bishop Mp and Fulmer Te and Gallant Dm},
  journal={Current Therapeutic Research-clinical and Experimental},
  year={1966},
  volume={8},
  pages={509}
}
16 Citations
A double-blind comparison of melperone and thiothixene in psychotic women using a new rating scale, the CPRS
TLDR
Treatment with both drugs was associated with significant reductions in morbidity as estimated by several measures of therapeutic effect from the CPRS, by the NOSIE scale and by global ratings.
Effects of melperone and thiothixene on prolactin levels in cerebrospinal fluid and plasma of psychotic women
TLDR
The results indicate that with the doses used thiothixene causes a more marked and long lasting blockade of central dopamine receptors controlling prolactin release, which is more potent and also more long acting than melperone.
Monoamine metabolite levels in cerebrospinal fluid of psychotic women treated with melperone or thiothixene
TLDR
The results supply evidence that thiothixene accelerates central dopamine metabolism in man, presumably by blocking DA receptors, and indicate that both drugs cause long-term changes in the activity ratios of central monoamine systems.
Psychopharmacological effects of thiothixene and related compounds
  • A. Weissman
  • Chemistry, Psychology
    Psychopharmacologia
  • 2004
TLDR
The present report describes several psychopharmacological actions of thiothixene and compares them with those of chlorpromazine, prochlorperazine, and the phenothiazine analogous to thiOTHixene, thioproperazine and the geometric isomers of other 9-unsaturated thioxanthenes.
Trifluoperazine for schizophrenia.
TLDR
There appears to be enough consistency over different outcomes and periods to confirm that trifluoperazine is an antipsychotic of similar efficacy to other commonly used neuroleptics for people with schizophrenia.
The dual action of thiothixene.
TLDR
The clinical literature of thiothixene in adult schizophrenic patients was reviewed in an attempt to correlate optimal dose with chosen indices of the dual action hypothesis; overall efficacy did not correlate with dosage or with activation-stimulation, but showed the presence of an antipsychotic component at least equal to standard antipsychotics.
Thiothixene in the treatment of mixed anxiety and depression.
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