Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells.

@article{Kim2008ThiosulfinatesFA,
  title={Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells.},
  author={So-Yeon Kim and Kyoung-Wuk Park and J P Kim and I J Jeong and M Y Byun and Jung-Eun Park and Sung-Tae Yee and Kee-Hong Kim and Johng Sik Rhim and Koji Yamada and K I Seo},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 1},
  pages={199-204}
}
This study was aimed to evaluate the apoptotic effects of thiosulfinates purified from Allium tuberosum L. on PC-3 human prostate cancer cells, and to elucidate detailed apoptosis mechanisms. Thiosulfinates significantly decrease viable cell numbers in dose- and time-dependent manners by apoptotic cell death via DNA fragmentation, chromatin condensation… CONTINUE READING