Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice

@article{Bermudez2003ThiosemicarbazoleC,
  title={Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice},
  author={L. Bermudez and Robert Reynolds and P. Kolonoski and P. Aralar and C. Inderlied and L. S. Young},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2003},
  volume={47},
  pages={2685 - 2687}
}
  • L. Bermudez, Robert Reynolds, +3 authors L. S. Young
  • Published 2003
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • Key ResultIn vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens.Expand Abstract
    32 Citations

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384
    • 31
    • PDF
    Phenylethyl Butyrate Enhances the Potency of Second-Line Drugs against Clinical Isolates of Mycobacterium tuberculosis
    • 12
    • PDF
    EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets
    • 116
    • PDF

    References

    SHOWING 1-10 OF 18 REFERENCES
    Thiacetazone: in vitro activity against Mycobacterium avium and M. tuberculosis.
    • 20
    Roxithromycin alone and in combination with either ethambutol or levofloxacin for disseminated Mycobacterium avium infections in beige mice.
    • 10
    • PDF
    Mycobacterium avium Grown inAcanthamoeba castellanii Is Protected from the Effects of Antimicrobials
    • 111
    • PDF
    Determination of in vitro susceptibility of Mycobacterium avium complex isolates to antimycobacterial agents by various methods.
    • 87
    • PDF
    Treatment of Mycobacterium avium in Human Immunodeficiency Virus-Infected Individuals
    • 8
    Clarithromycin Therapy for Bacteremic Mycobacterium avium Complex Disease
    • 273
    The Mycobacterium avium complex.
    • 488
    • PDF