Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice

  title={Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice},
  author={L. Bermudez and Robert Reynolds and P. Kolonoski and P. Aralar and C. Inderlied and L. S. Young},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={2685 - 2687}
  • L. Bermudez, Robert Reynolds, +3 authors L. S. Young
  • Published 2003
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • Key ResultIn vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens.Expand Abstract
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