Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.

  title={Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.},
  author={Luiz E. Bermudez and Robert Reynolds and Peter Kolonoski and Pricilla Aralar and Clark B Inderlied and Lowell S. Young},
  journal={Antimicrobial agents and chemotherapy},
  volume={47 8},
In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single… CONTINUE READING

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