Thioridazine potentiates the effect of a beta-lactam antibiotic against Staphylococcus aureus independently of mecA expression.

@article{Poulsen2013ThioridazinePT,
  title={Thioridazine potentiates the effect of a beta-lactam antibiotic against Staphylococcus aureus independently of mecA expression.},
  author={Marianne \O. Poulsen and Kirstine Jacobsen and Mette Thorsing and Nadia R D Kristensen and Julie Clasen and Eva Maria Sternkopf Lilleb{\ae}k and Marianne Nielsine Skov and Birgitte Haahr Kallipolitis and Hans J\orn J Kolmos and Janne Kudsk Klitgaard},
  journal={Research in microbiology},
  year={2013},
  volume={164 2},
  pages={181-8}
}
The neuroleptic antipsychotic derivate thioridazine has been shown to increase the susceptibility of a methicillin-resistant Staphylococcus aureus (MRSA) isolate towards dicloxacillin. The aim of this study was to investigate the combinatorial effect of the two drugs on a broad selection of staphylococcal strains by analyzing a large collection of MRSA strains carrying different types of SCCmec, as well as MSSA strains. Transcription and translation of the resistance marker PBP2a encoded by… CONTINUE READING

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