Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.

@article{Dutta2013ThioridazineLB,
  title={Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.},
  author={Noton K Dutta and Michael L. Pinn and Mingming Zhao and Michelle A. Rudek and Petros C Karakousis},
  journal={The Journal of antimicrobial chemotherapy},
  year={2013},
  volume={68 6},
  pages={1327-30}
}
OBJECTIVES The antipsychotic drug thioridazine is active in the murine model of tuberculosis infection, which is predominantly intracellular in nature. Recent clinical reports suggest that thioridazine may play a role in the treatment of drug-resistant tuberculosis. We studied the tuberculocidal activity of thioridazine in guinea pigs, which develop necrotic lung granulomas histologically resembling their human counterparts. METHODS Pharmacokinetic studies were performed in guinea pigs to… CONTINUE READING

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