Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.

@article{Rodrigues2002ThioridazineIW,
  title={Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.},
  author={Tiago Rodrigues and Antonio Cardozo dos Santos and Ac{\'a}cio A Pigoso and F{\'a}bio E Mingatto and S{\'e}rgio Akira Uyemura and Carlos Curti},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 1},
  pages={136-42}
}
We evaluated the effects of the phenothiazine derivative thioridazine on mechanisms of mitochondria potentially implicated in apoptosis, such as those involving reactive oxygen species (ROS) and cytochrome c release, as well as the involvement of drug interaction with mitochondrial membrane in these effects. Within the 0 - 100 microM range thioridazine did not reduce the free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH) nor did it chelate iron. However, at 10 microM thioridazine showed… CONTINUE READING