Thioredoxins and glutaredoxins: unifying elements in redox biology.

  title={Thioredoxins and glutaredoxins: unifying elements in redox biology.},
  author={Yves Meyer and Bob B. Buchanan and Florence Vignols and Jean-Philippe Reichheld},
  journal={Annual review of genetics},
Since their discovery as a substrate for ribonucleotide reductase (RNR), the role of thioredoxin (Trx) and glutaredoxin (Grx) has been largely extended through their regulatory function. Both proteins act by changing the structure and activity of a broad spectrum of target proteins, typically by modifying redox status. Trx and Grx are members of families with multiple and partially redundant genes. The number of genes clearly increased with the appearance of multicellular organisms, in part… CONTINUE READING
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