Thioredoxin-related mechanisms in hyperoxic lung injury in mice.

  title={Thioredoxin-related mechanisms in hyperoxic lung injury in mice.},
  author={Trent E. Tipple and Stephen E. Welty and Lynette K. Rogers and Thomas N Hansen and Young-Eun Choi and James P. Kehrer and Charles V Smith},
  journal={American journal of respiratory cell and molecular biology},
  volume={37 4},
Reduction of glutathione disulfide (GSSG) to glutathione (GSH) by glutathione reductase (GR) enhances the efficiency of GSH-dependent antioxidant activities. However, GR-deficient (a1Neu) mice are less susceptible to acute lung injury from continuous exposure to > 95% O(2) (96 h: 6.9 +/- 0.1 g right lung/kg body versus room air 3.6 +/- 0.3) than are C3H/HeN control mice (10.6 +/- 1.3 versus 4.2 +/- 0.3, P < 0.001). a1Neu mice have greater hepatic thioredoxin (Trx)1 and Trx2 levels than do C3H… CONTINUE READING
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