Thioredoxin reductase - its role in epidermal redox status.

  title={Thioredoxin reductase - its role in epidermal redox status.},
  author={Karin Uta Schallreuter and John P. M. Wood},
  journal={Journal of photochemistry and photobiology. B, Biology},
  volume={64 2-3},
The human epidermis with an area of 1.8 m(2) is the outer most layer of the human body. Hence, this organ plays a pivotal role in the defence against reactive oxygen species (ROS) generated by UV or X-ray exposure, heat and other sources. Consequently, a plethora of defence mechanisms exist controlling the redox status in this compartment. The role of thioredoxin reductase (TR), thioredoxin (T) in antioxidant defence has gained widespread recognition. In the past it has been shown that… CONTINUE READING


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