Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages.

@article{Kalantari2008ThioredoxinRN,
  title={Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages.},
  author={Parisa Kalantari and Vivek Narayan and Sathish Kumar Natarajan and Kambadur Muralidhar and Ujjawal H Gandhi and Hema Vunta and Andrew J. Henderson and Kumble Sandeep Prabhu},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 48},
  pages={33183-90}
}
Epidemiological studies suggest a correlation between severity of acquired immunodeficiency syndrome (AIDS) and selenium deficiency, indicating a protective role for this anti-oxidant during HIV infection. Here we demonstrate that thioredoxin reductase-1 (TR1), a selenium-containing pyridine nucleotide-disulfide oxidoreductase that reduces protein disulfides to free thiols, negatively regulates the activity of the HIV-1 encoded transcriptional activator, Tat, in human macrophages. We used a… CONTINUE READING
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