Thioredoxin-mediated Denitrosylation Regulates Cytokine-induced Nuclear Factor κB (NF-κB) Activation*

@article{Kelleher2013ThioredoxinmediatedDR,
  title={Thioredoxin-mediated Denitrosylation Regulates Cytokine-induced Nuclear Factor κB (NF-κB) Activation*},
  author={Zachary T. Kelleher and Yonggang Sha and Matthew W Foster and William M. Foster and Michael T. Forrester and Harvey E. Marshall},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={289},
  pages={3066 - 3072}
}
Background: S-nitrosylation inhibits mediators of the immune response including the transcription factor NF-κB (p50/p65). Results: Exogenous and endogenous inhibitors of thioredoxin prevent p65 denitrosylation and downstream activation of NF-κB. Conclusion: Thioredoxin activates inflammatory signaling through targeted denitrosylation of NF-κB. Significance: Mechanisms that augment protein S-nitrosylation can be utilized to suppress the immune response. S-nitrosylation of nuclear factor κB (NF… CONTINUE READING

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