Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria.

@article{Balmer2004ThioredoxinLR,
  title={Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria.},
  author={Y. Balmer and W. Vensel and C. Tanaka and W. Hurkman and E. Gelhaye and N. Rouhier and J. Jacquot and W. Manieri and P. Schürmann and M. Droux and B. Buchanan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 8},
  pages={
          2642-7
        }
}
  • Y. Balmer, W. Vensel, +8 authors B. Buchanan
  • Published 2004
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Mitochondria contain thioredoxin (Trx), a regulatory disulfide protein, and an associated flavoenzyme, NADP/Trx reductase, which provide a link to NADPH in the organelle. Unlike animal and yeast counterparts, the function of Trx in plant mitochondria is largely unknown. Accordingly, we have applied recently devised proteomic approaches to identify soluble Trx-linked proteins in mitochondria isolated from photosynthetic (pea and spinach leaves) and heterotrophic (potato tubers) sources… Expand
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TLDR
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References

SHOWING 1-10 OF 42 REFERENCES
Proteomics gives insight into the regulatory function of chloroplast thioredoxins
Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and playExpand
Comprehensive survey of proteins targeted by chloroplast thioredoxin
TLDR
The immobilized mutant of m-type Trx, in which an internal cysteine at the active site was substituted with serine, was immobilized on cyanogen bromide-activated resin, and four proteins were efficiently acquired when they formed the mixed-disulfide intermediates with the immobilized Trxs. Expand
A strategy for the identification of proteins targeted by thioredoxin
TLDR
These findings open the door to the identification of proteins targeted by thioredoxin in a wide range of systems, thereby enhancing the understanding of its function and extending its technological and medical applications. Expand
Isolation and characterization of a thioredoxin-dependent peroxidase from Chlamydomonas reinhardtii.
TLDR
It is shown that the Chlamydomonas peroxiredoxin (Ch-Prx1) is active with various thioredoxin isoforms, functions as an antioxidant toward reactive oxygen species (ROS), and protects DNA against ROS-induced degradation. Expand
PLANT THIOREDOXIN SYSTEMS REVISITED.
TLDR
Recent developments that have provided new insights into the structures of several components and into the mechanism of action of the thioredoxin systems in plants are summarized. Expand
Identification and characterization of a mitochondrial thioredoxin system in plants
TLDR
The thiOREDoxin and the NADPH-dependent thioredoxin reductase described here are proposed to constitute a functional plant mitochondrial thioringoxin system. Expand
A survey of the plant mitochondrial proteome in relation to development
TLDR
The comparative analysis of soluble mitochondrial proteomes led to the identification of a number of proteins which were specifically present in root or in seed mitochondria, thus revealing the impact of tissue differentiation at the mitochondrial level. Expand
PLANT MITOCHONDRIA AND OXIDATIVE STRESS: Electron Transport, NADPH Turnover, and Metabolism of Reactive Oxygen Species.
  • I. Møller
  • Biology, Medicine
  • Annual review of plant physiology and plant molecular biology
  • 2001
TLDR
The alternative oxidase and possibly NDin(NADH) function to limit mitochondrial ROS production by keeping the ETC relatively oxidized, together with small antioxidants such as glutathione, that help remove ROS. Expand
Mitochondrial protein import: modification of sulfhydryl groups of the inner mitochondrial membrane import machinery in Solanum tuberosum inhibits protein import
TLDR
Redox and conformational status of SH groups located on the outer surface of the inner mitochondrial membrane were essential for protein import into mitochondria, indicated that MPB does not cross the inner membrane, and the inhibitory effect of NEM, MPB, DTNB and Cu2+ inhibited import of the NEM-modified pF1β into intact mitochondria. Expand
The impact of oxidative stress on Arabidopsis mitochondria.
TLDR
Using H2O2 as a model stress, further work revealed that this treatment induced a protease activity in isolated mitochondria, putatively responsible for the degradation of oxidatively damaged mitochondrial proteins and that O2 consumption by mitochondria was significantly decreased by H2 O2 treatment. Expand
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