Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.

  title={Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.},
  author={Douglas A. Mitchell and Sarah U. Morton and Nathaniel B. Fernhoff and Michael A Marletta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 28},
S-nitrosation is a posttranslational, oxidative addition of NO to cysteine residues of proteins that has been proposed as a cGMP-independent signaling pathway [Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005) Nat Rev Mol Cell Biol 6:150-166]. A paradox of S-nitrosation is that only a small set of reactive cysteines are modified in vivo despite the promiscuous reactivity NO exhibits with thiols, precluding the reaction of free NO as the primary mechanism of S-nitrosation. Here we… CONTINUE READING
Highly Cited
This paper has 75 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 43 extracted citations

Biochemistry of Oxidative Stress

Advances in Biochemistry in Health and Disease • 2016
View 10 Excerpts
Highly Influenced

Redox Regulatory Mechanism of Transnitrosylation by Thioredoxin*

Molecular & cellular proteomics : MCP • 2010
View 4 Excerpts
Highly Influenced

75 Citations

Citations per Year
Semantic Scholar estimates that this publication has 75 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 12 references

Protein Expression Purif

JM Scheer, JA Wells, MJ Romanowski

Structure (London) 12:1361–1371

MJ Romanowski, JM Scheer, T O’Brien, RS McDowell
View 1 Excerpt

Cell Death Differ 10:864–869

B Brune

Trends Mol Med

MW Foster, TJ McMahon, JS Stamler

Sci STKE 2001 : RE 1

P Lane, G Hao, SS Gross

Biochim Biophys Acta

JW Denninger, MA Marletta

Nitric Oxide 1:275–281

S Dimmeler, AM Zeiher

Anal Biochem 238:150–158

JA Cook, SY Kim, +7 authors AM Miles
View 1 Excerpt

Structure (London) 4:613–620

J Qin, GM Clore, WP Kennedy, J Kuszewski, AM Gronenborn

Structure (London) 4:735–751

A Weichsel, JR Gasdaska, G Powis, WR Montfort