Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle.

Abstract

Insulin resistance (IR) is an important determinant of type-2 diabetes mellitus (T2DM). Free fatty acids (FFAs) induce IR by various mechanisms. A surfeit of circulating FFA leads to intra-myocellular lipid accumulation that induces mitochondrial ROS generation and worsens IR. However, the molecular mechanisms behind are unclear. We identified thioredoxin… (More)
DOI: 10.1016/j.bbrc.2016.09.168

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