Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo.

@article{Park2014ThioredoxininteractingPM,
  title={Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo.},
  author={Min-Jung Park and Dong-Il Kim and Seul-ki Lim and J Choi and Jong-choon Kim and Kyung Chul Yoon and J K Lee and Jae Hyuk Lee and Ho-Jae Han and In-Pyo Choi and H Kim and Soo Hyun Park},
  journal={Journal of hepatology},
  year={2014},
  volume={61 5},
  pages={1151-7}
}
BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and type 2 diabetes. Thioredoxin-interacting protein (TXNIP) regulates the cellular redox state and metabolism and has been linked to many diseases, including diabetes. Therefore, we examined the role of TXNIP in hepatic steatosis in vitro and in vivo. METHODS Lipogenic and inflammatory proteins produced by hepatocytes treated with palmitic acid (PA) or transfected with TXNIP or Txnip siRNA were… CONTINUE READING