Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.

@article{Abdelsaid2013ThioredoxininteractingPE,
  title={Thioredoxin-interacting protein expression is required for VEGF-mediated angiogenic signal in endothelial cells.},
  author={Mohammed A. Abdelsaid and Suraporn Matragoon and Azza B El-Remessy},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={19 18},
  pages={2199-212}
}
AIMS Thioredoxin-interacting protein (TXNIP) contributes to cellular redox-state homeostasis via binding and inhibiting thioredoxin (TRX). Increasing evidence suggests that cellular redox homeostasis regulates vascular endothelial growth factor (VEGF)-mediated signaling. This study aims to examine the redox-dependant role of TXNIP in regulating VEGF-mediated S-glutathionylation and angiogenic signaling. TXNIP-knockout mice (TKO) or wild-type (WT) treated with the reduced glutathione (GSH… CONTINUE READING

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