Thioredoxin interacting protein expression in the urinary sediment associates with renal function decline in type 1 diabetes.


AIMS Thioredoxin interacting protein (TXNIP), an inhibitor of antioxidant thioredoxin (Trx), is upregulated by hyperglycemia and implicated in pathogenesis of diabetes complications. We evaluated mRNA expressions of genes encoding TXNIP and Trx (TXN) in urinary sediment and peripheral blood mononuclear cells (PBMC) of type 1 diabetes (T1D) patients with… (More)
DOI: 10.3109/10715762.2015.1109083