Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.

  title={Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.},
  author={Parth Patwari and William A. Chutkow and Kiersten S Cummings and Valerie L. R. M. Verstraeten and Jan Lammerding and Eric R. Schreiter and Richard T Lee},
  journal={The Journal of biological chemistry},
  volume={284 37},
Thioredoxin-interacting protein (Txnip), originally characterized as an inhibitor of thioredoxin, is now known to be a critical regulator of glucose metabolism in vivo. Txnip is a member of the alpha-arrestin protein family; the alpha-arrestins are related to the classical beta-arrestins and visual arrestins. Txnip is the only alpha-arrestin known to bind thioredoxin, and it is not known whether the metabolic effects of Txnip are related to its ability to bind thioredoxin or related to… CONTINUE READING
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