Thioredoxin in human and experimental sepsis*

@article{Hofer2009ThioredoxinIH,
  title={Thioredoxin in human and experimental sepsis*},
  author={Stefan Hofer and Claudia Rosenhagen and Hajime Nakamura and Junji Yodoi and Christian Bopp and Johannes B. Zimmermann and Meike Goebel and Peter Schemmer and Kartrin Hoffmann and Klaus Schulze-Osthoff and Raoul Breitkreutz and Markus A. Weigand},
  journal={Critical Care Medicine},
  year={2009},
  volume={37},
  pages={2155-2159}
}
Introduction: Thioredoxin (TRX) is assumed to be beneficial in acute inflammatory diseases because of its potent antioxidant properties and an inhibitory effect on neutrophil evasion into sites of inflammation. Objective: To compare plasma levels of thioredoxin in septic patients and to investigate the role of thioredoxin in a polymicrobial septic mouse model. Design and Interventions: A combined single-center noninterventional clinical observation study and randomized controlled experimental… 
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33 Citations
Highly Influential Citations
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Background Citations
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Results Citations
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33 Citations

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Thioredoxin a novel biomarker of post‐injury sepsis
Redox Responses in Patients with Sepsis: High Correlation of Thioredoxin-1 and Macrophage Migration Inhibitory Factor Plasma Levels
TLDR
Proinflammatory/~oxidative and anti-inflammatory/ ~ oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidatives response.
Thioredoxin-1 Increases Survival in Sepsis by Inflammatory Response Through Suppressing Endoplasmic Reticulum Stress
TLDR
The results suggest that Trx-1 may play protective role in extending survival in sepsis by regulating inflammatory response through suppressing ER stress.
Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor
TLDR
The link between MIF and Trx highlighted in this study has implications for future investigations into the pathogenesis of SIRS/sepsis and Comparisons between mediators suggest a unique correlation of Trx with MIF.
Attenuation of Hyperoxic Lung Injury in Newborn Thioredoxin-1-Overexpressing Mice through the Suppression of Proinflammatory Cytokine mRNA Expression
TLDR
It is suggested that in newborn mice TRX ameliorates hyperoxic lung injury during recovery likely through the suppression of proinflammatory cytokines.
Thioredoxin-1 (Trx1) : a new target in the treatment of cardiovascular diseases
The cardiovascular diseases (CVDs), resulting from complications of atherosclerosis, remain the leading cause of morbidity and death worldwide. Atherosclerosis as a chronic inflammatory disease,…
Thioredoxin Therapy: Challenges in Translational Research
TLDR
Recently, it is shown that recombinant human TRX-1 administration decreases the mortality rate and ameliorates acute lung injury in influenza A virus-infected mice, probably through its antioxidative and anti-inflammatory actions.
Circulating Levels of Peroxiredoxin 4 as a Novel Biomarker of Oxidative Stress in Patients with Sepsis
TLDR
Elevated serum levels of the antioxidant Prx4 were associated with an increased disease severity and adverse outcome of critically ill patients with sepsis, and may be a helpful new biomarker for diagnosing, monitoring, and risk assessing these patients.
Thioredoxin in Post-Injury Sepsis And Ards
TLDR
TRX-levels in trauma patients and the possible correlation to secondary complications such as post-injury sepsis and acute respiratory distress syndrome (ARDS) have to the authors' knowledge not been studied previously.
Cardiac-specific overexpression of thioredoxin 1 attenuates mitochondrial and myocardial dysfunction in septic mice.
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References

SHOWING 1-10 OF 57 REFERENCES
Extracellular thioredoxin levels are increased in patients with acute lung injury
TLDR
Extracellular thioredoxin levels are raised in patients with ALI, particularly of pulmonary origin, and have a significant positive association with IL-8, a useful indication of inflammation in ALI.
Thioredoxin blood level increases after severe burn injury.
TLDR
The demonstration of TRX release in burn injuries indicates that the TRX system is involved in a rapid antioxidant defense, coagulation processes, cell growth, and control of the extracellular peroxide tone intimately linked to cytoprotection and wound healing in burns.
Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis.
  • S. Ohashi, A. Nishio, +16 authors T. Chiba
  • Biology, Medicine
    American journal of physiology. Gastrointestinal and liver physiology
  • 2006
TLDR
It is suggested that TRX-1 has potent antioxidant and anti-inflammatory actions in experimental acute pancreatitis and might be a new therapeutic strategy to improve the prognosis of severe acute Pancreatitis.
Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS
TLDR
It is proposed that elevated plasma Trx in HIV-infected individuals with low CD4 T cell counts directly impairs survival by blocking pathogen-induced chemotaxis, effectively eliminating the last (innate) barrier against establishment of opportunistic and other infections in these immunodeficient individuals.
Persistently low plasma thioredoxin is associated with meningococcal septic shock in children
TLDR
Children with MSS exhibit persistently low plasma levels of Trx during acute illness and in convalescence, and trx, IL-1β, and TNF-α levels were not correlated with predicted mortality as assessed by the paediatric risk of mortality (PRISM) score.
Protection from septic shock by neutralization of macrophage migration inhibitory factor
TLDR
It is reported here that macrophage migration inhibitory factor (MIF) is a critical mediator of septic shock and a new target for therapeutic intervention is identified.
Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis.
Thioredoxin: friend or foe in human disease?
Thioredoxin-1 Ameliorates Myosin-Induced Autoimmune Myocarditis by Suppressing Chemokine Expressions and Leukocyte Chemotaxis in Mice
TLDR
TRX-1 attenuates EAM by suppressing chemokine expressions and leukocyte chemotaxis in mice by significantly suppressed cardiac macrophage inflammatory protein (MIP)-1&agr;, MIP-2, and 8-hydroxydeoxyguanosine expression and macrophages infiltration into the heart in EAM.
Elevation of plasma thioredoxin levels in HIV-infected individuals.
TLDR
Increases in plasma Trx levels correlate with decreases in monochlorobimane staining and with changes in surface antigen expression that occur in the later stages of HIV infection, suggesting that elevation of plasma TrX levels may be an important component of advanced HIV disease.
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