Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response

@article{Kim2003ThioredoxindependentRR,
  title={Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response},
  author={Yong-Chul Kim and Yoshimi Yamaguchi and Norihiko Kondo and Hiroshi Masutani and Junji Yodoi},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1860-1865}
}
Thioredoxin is a redox-regulating protein, the expression of which is induced by various forms of oxidative stress. Thioredoxin controls the interactions of various transcription factors through redox regulation. In K562 cells, we have previously reported that hemin induces activation of the thioredoxin gene by regulating NF-E2-related factor (Nrf2) through the antioxidant responsive element (ARE). We showed here that tert-butylhydroquinone (tBHQ), an electrophile stressor, activates the… CONTINUE READING