Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice.

@article{Ahsan2009ThioredoxinbindingPD,
  title={Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice.},
  author={Md Kaimul Ahsan and Hiroaki Okuyama and Yuma Hoshino and Shin-ichi Oka and Hiroshi Masutani and Junji Yodoi and H. Richard Nakamura},
  journal={Antioxidants & redox signaling},
  year={2009},
  volume={11 10},
  pages={2573-84}
}
In nonalcoholic fatty liver disease, oxidative stress is believed to play a crucial role as a second-hit for the progression of simple steatosis to steatohepatitis. Thioredoxin (TRX) is a potent antioxidant molecule that exerts anti-apoptotic and anti-inflammatory functions. TRX-binding protein-2 (TBP-2) is an endogenous negative regulator of TRX. Deficiency of TBP-2 in mice causes hyperlipidemia, hepatic steatosis, hypoglycemia, and bleeding tendency, resembling Reye syndrome in a fasting… CONTINUE READING