Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.

  title={Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.},
  author={Anu Shah and Ling Xia and Elodie A.Y. Masson and Chloe Gui and Abdul Momen and Eric Akihiko Shikatani and Mansoor Husain and Susan E Quaggin and R. W. St. John and Ivan George Fantus},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={26 12},
Expression of thioredoxin-interacting protein (TxNIP), an endogenous inhibitor of the thiol oxidoreductase thioredoxin, is augmented by high glucose (HG) and promotes oxidative stress. We previously reported that TxNIP-deficient mesangial cells showed protection from HG-induced reactive oxygen species, mitogen-activated protein kinase phosphorylation, and collagen expression. Here, we investigated the potential role of TxNIP in the pathogenesis of diabetic nephropathy (DN) in vivo. Wild-type… CONTINUE READING
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