Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

@article{Ishrat2014ThioredoxinInteractingPA,
  title={Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice},
  author={Tauheed Ishrat and Islam N. Mohamed and Bindu A. Pillai and Sahar A. Soliman and Abdelrahman Y. Fouda and Adviye Ergul and Azza B El-Remessy and Susan C Fagan},
  journal={Molecular Neurobiology},
  year={2014},
  volume={51},
  pages={766-778}
}
Redox imbalance in the brain significantly contributes to ischemic stroke pathogenesis, but antioxidant therapies have failed in clinical trials. Activation of endogenous defense mechanisms may provide better protection against stroke-induced oxidative injury. TXNIP (thioredoxin-interacting protein) is an endogenous inhibitor of thioredoxin (TRX), a key antioxidant system. We hypothesize that TXNIP inhibition attenuates redox imbalance and inflammation and provides protection against a… CONTINUE READING