Thioredoxin Ameliorates Cutaneous Inflammation by Regulating the Epithelial Production and Release of Pro-Inflammatory Cytokines

@inproceedings{Tian2013ThioredoxinAC,
  title={Thioredoxin Ameliorates Cutaneous Inflammation by Regulating the Epithelial Production and Release of Pro-Inflammatory Cytokines},
  author={Hai Tian and Yoshiyuki Matsuo and Atsushi Fukunaga and Ryusuke Ono and Chikako Nishigori and Junji Yodoi},
  booktitle={Front. Immunol.},
  year={2013}
}
Human thioredoxin-1 (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-. It has been demonstrated that systemic administration and transgenic overexpression of TRX ameliorate inflammation in various animal models, but its anti-inflammatory mechanism is not well characterized. We investigated the anti-inflammatory effects of topically applied recombinant human TRX (rhTRX) in a murine irritant contact dermatitis (ICD) induced by croton oil. Topically applied… CONTINUE READING
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