• Corpus ID: 87035732

Thioredoxin-2(TRX-2)is an essential gene regulating mitochondria-dependent apoptosis

@inproceedings{2002Thioredoxin2TRX2isAE,
  title={Thioredoxin-2(TRX-2)is an essential gene regulating mitochondria-dependent apoptosis},
  author={田中 亨},
  year={2002}
}
Results ASK 1 and Trx 2 Form a Complex in Mitochondria That Is Dissociated in Response to TNF / ROS
TLDR
It is shown that ASK1 is localized in both cytoplasm and mitochondria of endothelial cells (ECs) where it binds to cytosolic (Trx1) and mitochondrial thioredoxin (trx2), respectively, and that Trx1 and Trx2 cooperatively inhibit ASK 1 activities.
Thioredoxin-2 protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy and apoptosis in H9c2 cardiomyocytes.
TLDR
The data indicated that Trx2 protects cardiomyocytes under OGD/R by inhibiting autophagy and apoptosis, and may be a crucial regulatory protein during I/R-inducedCardiomyocyte injury and death.
Inhibition of skin fibrosis in systemic sclerosis by botulinum toxin B via the suppression of oxidative stress
TLDR
It is found that BTX‐B injection significantly reduced dermal thickness and inflammatory cell infiltration in bleomycin‐induced skin fibrosis lesion in mice and may have a therapeutic effect onskin fibrosis in SSc.
Oxidative stress in cell and tissue damage and selenium-based therapeutics in cancer
TLDR
Redox active selenium compounds are promising candidates for the application in cancer therapy as well as target site modifications, multidrug resistant efflux pumps, or upregulation of redox proteins and detoxification pathways.
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
TLDR
Both the intraand extra-cellular redox balance is perturbed in chronic inflammation, and may be corrected by treatment of the underlying disease.
Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
TLDR
Evidence supporting the significant contribution of regulatory mechanisms ofTXNIP with the development of brain diseases is summarized, pharmacological strategies of targeting TXNIP are explored, and obstacles to be considered for efficient clinical translation are outlined.
The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury
TLDR
This review attempts to make the case that in addition to interacting with thioredoxin, Txnip contributes to some of the pathological consequences of myocardial ischemia and infarction through endogenous signals in multiple molecular mechanisms.
Intramyocardial injection of thioredoxin 2-expressing lentivirus alleviates myocardial ischemia-reperfusion injury in rats.
TLDR
The study indicates that upregulation of Trx2 protect the myocardium from MIRI and is involved in the inhibition of apoptosis and autophagy and is a promising therapeutic strategy for attenuating M IRI.
Trimodal rescue of hind limb ischemia with growth factors, cells, and nanocarriers: fundamentals to clinical trials.
TLDR
In this review, the basic mechanism through which growth factors exert their beneficial properties to rescue the ischemic limb is extensively discussed and clinical trials based on growth factor and stem cell therapy to treat critical limb ischemia are considered.
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