Thioredoxin 1 regulation of protein S-desulfhydration

  title={Thioredoxin 1 regulation of protein S-desulfhydration},
  author={Youngjun Ju and Ling-Yun Wu and Guangdong Yang},
  booktitle={Biochemistry and biophysics reports},
The importance of H2S in biology and medicine has been widely recognized in recent years, and protein S-sulfhydration is proposed to mediate the direct actions of H2S bioactivity in the body. Thioredoxin 1 (Trx1) is an important reducing enzyme that cleaves disulfides in proteins and acts as an S-denitrosylase. The regulation of Trx1 on protein S-sulfhydration is unclear. Here we showed that Trx1 facilitates protein S-desulfhydration. Overexpression of Trx1 attenuated the basal level and H2S… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 34 references

Protein S-sulfhydration as a major source of H2S bioactivity

  • G. Yang
  • Recept. Clin. Investig. 1
  • 2014
1 Excerpt