Thioredoxin 1 regulation of protein S-desulfhydration

@inproceedings{Ju2016Thioredoxin1R,
  title={Thioredoxin 1 regulation of protein S-desulfhydration},
  author={Youngjun Ju and Ling-Yun Wu and Guangdong Yang},
  booktitle={Biochemistry and biophysics reports},
  year={2016}
}

• Youngjun Ju, Ling-Yun Wu, Guangdong Yang
• Published in Biochemistry and biophysics reports 2016
• DOI:10.1016/j.bbrep.2015.11.012

The importance of H2S in biology and medicine has been widely recognized in recent years, and protein S-sulfhydration is proposed to mediate the direct actions of H2S bioactivity in the body. Thioredoxin 1 (Trx1) is an important reducing enzyme that cleaves disulfides in proteins and acts as an S-denitrosylase. The regulation of Trx1 on protein S-sulfhydration is unclear. Here we showed that Trx1 facilitates protein S-desulfhydration. Overexpression of Trx1 attenuated the basal level and H2S… CONTINUE READING

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